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The chromosome breakage rates in 244 cases of the infertility couples
Yu Hongliang,Chang Mingxiu,Cao Henghai,Bo Liwei,Wang Yanli and Wu Yanhong
Strategic Study of CAE 2014, Volume 16, Issue 5, Pages 67-69
Keywords: infertility couples adverse pregnancy chromosome breakage
Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 827-858 doi: 10.1007/s11684-022-0948-8
Keywords: infertility stem cell therapy mesenchymal stem cells pluripotent stem cells
Applying TCM Constitution Theory to Infertility via Omics
Qi Wang
Engineering 2023, Volume 30, Issue 11, Pages 30-31 doi: 10.1016/j.eng.2023.05.005
Immunohistochemical measurement and expression of Mcl-1 in infertile testes
Raafat Hegazy,Abdelmonem Hegazy,Mustafa Ammar,Emad Salem
Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 361-367 doi: 10.1007/s11684-015-0395-x
The diagnosis of azoospermia represents a major challenge to andrologists as this condition may occur despite normal spermatogenesis and genital tracts. Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins involved in regulation of apoptosis in various cell types. This study aimed to investigate the immunohistochemical expression of Mcl-1 in testicular biopsies of subjects with azoospermia. Eighty-six cases with azoospermia were obtained from 509 infertile patients admitted to the Andrology Unit of the Zagazig University Hospitals from January 2010 to December 2011. Biopsies were diagnosed and classified using H&E-stained slide sections. The specimens were subjected to immunohistochemical staining for Mcl-1 and examined through light microscopy. Forty-five cases of maturation arrest (25 at spermatids and 20 at the spermatocytes), 31 cases of hypospermatogenesis (20 moderate and 11 severe), 5 cases of Sertoli?cell-only syndrome, 2 cases of basement membrane hyalinization, and 1 case of tubular and peritubular sclerosis were observed. Normal spermatogenesis was detected in 2 cases. A strong positive immunoreaction in Leydig cells was observed among all investigated specimens. A moderate reaction was detected in spermatocytes and spermatozoa in cases of normal spermatogenesis and hypospermatogenesis, but a negative reaction was detected in cases of maturation arrest and germ cell aplasia. Apoptosis was found to be associated with decreased rate of spermatogenesis. High apoptosis rates may result in azoospermia, which can occur despite normal spermatogenesis and absence of duct obstruction.
Keywords: spermatogenesis testis Mcl-1 expression immunohistochemical study infertility
Jian Li, Qi Wu, Ernest Hung Yu Ng, Ben Willem J. Mol, Xiao Ke Wu, Chi Chiu Wang
Engineering 2022, Volume 16, Issue 9, Pages 198-209 doi: 10.1016/j.eng.2021.07.009
Keywords: Male infertility Medicine Supplement Spontaneous pregnancy rate Sperm parameters
Research on Direction and Location for Danger Prediction of Coal or Rock Dynamic Disaster
Xiao Hohgfei,He Xueqiu,Feng Tao,Wang Enyuan
Strategic Study of CAE 2005, Volume 7, Issue 11, Pages 81-86
In order to use the non-touch electromagnetic emission (EME) method to better forecast or predict the danger of coal or rock dynamic disaster such as coal or gas outburst, rock or coal outburst and so on, the direction and location of dangerous areas, that is, how to ascertain the monitoring direction and position for EME, is studied. The research results show that according to the computation for the changing rules of EME signals in various directions by means of the coupling equation between EME and stress, and the EME numerical results comparisons for the designated monitored spot, the best monitoring direction and the direction with most stress or maximum dangers can be ascertained. When dynamically monitoring the EME signals in tunnel head-on in the course of tunnel excavation, the monitoring antenna should be laid at the middle height of tunnel and faced with the coal stratum direction. The outburst danger can be monitored by altering the antenna monitoring direction. The available scope of prediction distance can be determined in light of the stress concentration ascertained by numerical simulation for stress field. The EME measuring results on the spot show that it is feasible to study the direction and location of dangerous areas in predicting the danger of coal or rock dynamic disaster by means of the coupling between EME and stress.
Keywords: dynamic disaster danger prediction direction and location deformation and fracture of coal or rock couples
DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis
Xiuli Zhang, Zhizhou Xia, Xingyu Lv, Donghe Li, Mingzhu Liu, Ruihong Zhang, Tong Ji, Ping Liu, Ruibao Ren
Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 302-312 doi: 10.1007/s11684-021-0851-8
Keywords: Dcaf8 male infertility spermatogenesis
Xiaoke Wu, Chi Chiu Wang, Yijuan Cao, Jian Li, Zhiqiang Li, Hongli Ma, Jingshu Gao, Hui Chang, Duojia Zhang, Jing Cong, Yu Wang, Qi Wu, Xiaoxiao Han, Pui Wah Jacqueline Chung, Yiran Li, Xu Zheng, Lingxi Chen, Lin Zeng, Astrid Borchert, Hartmut Kuhn, Zi-Jiang Chen, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Heping Zhang, Richard S. Legro, Ben Willem J. Mol, Yongyong Shi
Engineering 2023, Volume 23, Issue 4, Pages 103-111 doi: 10.1016/j.eng.2022.08.013
Ovulation induction is a first-line medical treatment for infertility in polycystic ovary syndrome/em>, associated with phenylalanine and arachidonic acid metabolites, contributed to the failure of infertility
Keywords: Polycystic ovary syndrome Infertility Ovulation responses ZNF438 REC114 Whole-exome sequencing
Title Author Date Type Operation
The chromosome breakage rates in 244 cases of the infertility couples
Yu Hongliang,Chang Mingxiu,Cao Henghai,Bo Liwei,Wang Yanli and Wu Yanhong
Journal Article
Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism
Journal Article
Immunohistochemical measurement and expression of Mcl-1 in infertile testes
Raafat Hegazy,Abdelmonem Hegazy,Mustafa Ammar,Emad Salem
Journal Article
Effects of Medicines and Supplements on Spontaneous Pregnancy and Semen Parameters in Male Infertility
Jian Li, Qi Wu, Ernest Hung Yu Ng, Ben Willem J. Mol, Xiao Ke Wu, Chi Chiu Wang
Journal Article
Research on Direction and Location for Danger Prediction of Coal or Rock Dynamic Disaster
Xiao Hohgfei,He Xueqiu,Feng Tao,Wang Enyuan
Journal Article
DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis
Xiuli Zhang, Zhizhou Xia, Xingyu Lv, Donghe Li, Mingzhu Liu, Ruihong Zhang, Tong Ji, Ping Liu, Ruibao Ren
Journal Article
Novel Genetic Risk and Metabolic Signatures of Insulin Signaling and Androgenesis in the Anovulation of Polycystic Ovary Syndrome
Xiaoke Wu, Chi Chiu Wang, Yijuan Cao, Jian Li, Zhiqiang Li, Hongli Ma, Jingshu Gao, Hui Chang, Duojia Zhang, Jing Cong, Yu Wang, Qi Wu, Xiaoxiao Han, Pui Wah Jacqueline Chung, Yiran Li, Xu Zheng, Lingxi Chen, Lin Zeng, Astrid Borchert, Hartmut Kuhn, Zi-Jiang Chen, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Heping Zhang, Richard S. Legro, Ben Willem J. Mol, Yongyong Shi
Journal Article